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Message: Re: ACC 2019 Abstracts
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And Bear brings us back to science!  Like the look of the dementia abstract!

OK, here's another science topic:

We know that ABL works as an epigenetic ‘reader’ of histone and non-histone acetylation.  In doing so, it knocks BET proteins off acetylated proteins and prevents the upregulation of genes associated with inflammatory and oncogenic processes.  This article https://www.mdpi.com/2305-6320/6/1/24 indicates that ABL’s parent molecule (resveratrol) has other epigenetic capabilities, including activating both writers (acetylation and methylation enzymes) and erasers (de-acetylation and de-methylation enzymes).   Has there been any suggestion that ABL possesses epigenetic potential beyond BET inhibition?

 Thanks

Jupe

P.S.  Bear, not asking you to do all my homework for me – just pointing me in the right direction, if there is one, would be great!

 

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