Re: ACC 2019 Abstracts
in response to
by
posted on
Mar 04, 2019 03:40PM
And Bear brings us back to science! Like the look of the dementia abstract!
OK, here's another science topic:
We know that ABL works as an epigenetic ‘reader’ of histone and non-histone acetylation. In doing so, it knocks BET proteins off acetylated proteins and prevents the upregulation of genes associated with inflammatory and oncogenic processes. This article https://www.mdpi.com/2305-6320/6/1/24 indicates that ABL’s parent molecule (resveratrol) has other epigenetic capabilities, including activating both writers (acetylation and methylation enzymes) and erasers (de-acetylation and de-methylation enzymes). Has there been any suggestion that ABL possesses epigenetic potential beyond BET inhibition?
Thanks
Jupe
P.S. Bear, not asking you to do all my homework for me – just pointing me in the right direction, if there is one, would be great!