Two issues here. One is the issue of DM having a history of over-promising and under delivering. The other is reasonable expectation for BETonMACE timeline. DND, Narmac, Coldnewfie seem to be focusing on the former. Tada and I seem to be focusing on the latter. Both camps are correct if you stick to the respective issue. As for the latter, BETonMACE was still in the planning/approval stages through most of 2015, wasn't listed on EU Clinical Trials register or ClinicalTrials.gov until October 2015 and didn't start enrolling until October 2015. A reasonable expectation of trial timeline would start the clock from the actual trial listing or start of the trial enrollment due to the myriad of possibilities that can cause delays. 

BDAZ