Bear - I was going to ask what you have seen in the past for time to lock data base after safety follow-up completion. This is the area that has been left murky. From your post, I can see that is your question also. The times they have given are from fastest to July 17th to slowest to July 31st. This is of course with zero time to lock database after safety follow-ups. Adding some time for that gives maybe July 24th to August 7th. The time to lock the database is an unknown so if you have any past experience in this, it would be appreciated.