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Message: Reata, Bardoxolone, NRF2, CKD, Mitochondria, Inflammation, Redox Balance, Reactive Oxygen Species

Totally fascinating stuff. Unfortunately I haven't got a clue what you guys are talking about. Maybe after reading 400 or 500 articles like I did with epigenetics and all the other things surrounding the RVX208 technology I will at least have a little bit of a clue.

This all fits in though with the question for BDAZ the other day about the FDA and Blinded Trials.

As science is an evolution it wouldn't be unreasonable for the FDA processes to evolve along with science.

It took from the dawn of time until about the year 2000 for the genome to be mapped. Now we are in the epigenome and making some real progress. As knowledge increases and costs decrease the explosion of knowledge will change the way we approach many things that we have established patterns of doing things in the past. A couple of examples in technology would be cell phones. Where we used to carry this thing that looked something like a lunch box with a cord and a handset we now carry something that fits in our shirt pocket and has more computing power in it than the entirety of the Appolo Space Crafts. On the medical side when I was young and went to see the doctor the first thing he would do was to stick a thermometer in my mouth or another area and wait a couple of minutes to get a reading. Today when I go to see the doc they hold this gizmo up to my ear, push a button and get a more accurate reading than the previous mention methods.

As far as Blinded Trials and the FDA, as technology evolves so will the trial processes otherwise someone will be able to have an unfair advantage of knowing information way ahead of the curve of the masses. 

As far as this stuff you guys are talking about  with the mitochondria and processes surrounding it, it is so far ahead of the curve of the masses on this board that many could lose interest.

As fascinating as it is I'm hoping that we can keep on the RVX/Apabetalone track on this board.

tada

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