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Message: Re: Epigenetics and Coronavirus
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Mar 23, 2020 10:34AM
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Mar 23, 2020 10:54AM
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Mar 23, 2020 11:01AM
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Mar 23, 2020 11:22AM
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Mar 23, 2020 11:47AM
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Mar 23, 2020 03:31PM
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Mar 23, 2020 03:32PM

 "Don might have tried to get into one of the existing trials and failed"

City,

The paper indicates that the researchers collaborating with QBI folks are testing the identified drugs/compunds (including RVX-208) for anti-viral activity:

"Using a combination of a systematic chemoinformatic drug search with a pathway centric analysis, we uncovered close to 70 different drugs and compounds, including FDA approved drugs, compounds in clinical trials as well as preclinical compounds, targeting parts of the resulting network. We are currently testing these compounds for antiviral activity andencourage others to do the same as well as extract insights from the map that could have therapeutic value."

I think RVX is looking ahead to these researchers being successful in demonstrating in vitro anti-viral activity.  Next step is finding someone to partner with for some quick clinical work.  One potential group might be their friends at the Quebec Heart and Lung Institute who are already running the PAH trial:

https://www.ulaval.ca/en/about-us/media-centre/press-releases/press-releases-2019/pulmonary-arterial-hypertension-first-global-study-epigenetics-treat-disease

Jupe

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Mar 23, 2020 05:10PM
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Mar 23, 2020 05:14PM
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