"we infected Calu3 cells and then immediately treated them with either JQ1 or dBET6 for 48 hours,.."

"In A549-ACE2 cells treated with ABBV-744 at the time of infection,..."

"Mice were infected intranasally, and BET inhibitors were administered daily intraperitoneally or orally starting on the day of infection."

"our study focuses on the concurrent administration of BET inhibitors, JQ1 and ABBV-744, at the time of infection."

so timing of administration is critical. administering apabetalone too early in active infection phase would be like helping viral E protein's job of turning down inflammation. this made me think.. is cytokine storm related to this suppressed inflammation at the beginning of infection..?

also, to note,

"whereas BD2-specific inhibitors had the greatest effect in ameliorating inflammatory and autoimmune diseases (Gilan et al., 2020)"

does apabetalone have a potential for autoimmune diseases...?