Here's one you might consider with some of the SPQ funds - ONC, trades on the Toronto exchange, and is based in Calgary. Seems to be a decent price lately, in the mid 2's. I've been an investor too long a time, but what they are trying to do (get approval of a cancer therapy involving reovirus) is not an easy or quick thing. Just starting phase III trials.
Like the ROF, huge risk/reward. There is a private yahoo board (the so called V2 board) that is quite civil, with lots of technical guys. The public Yahoo board is mainly poor, what else is new.
Calling a spade a spade, this is a pump, but I'm holding until they get their results from Phase III and their up or down from the FDA, Health Canada and similar European authorities.
Still in NOT and ECU, tough sledding in both of those.