What we do know is that the trial went on for 27 median months vs design of 18 months.  I am reading DM's "rigorous academic requirements" as meaning did not meet 95% confidence interval, and the "data data data" statement in the conference call as meaning that the RRR was high...we just don't know how high.

Putting these 2 facts together, it is absolutely impossible to accept that the MACE rate for the placebo was what they had assumed in the trial design.  Placebo MACE rate MUST be lower...quite a bit lower.