BET inhibitor and BRD4 papers keep piling up
posted on
Sep 23, 2017 06:11PM
A few recently published papers related to BET inhibition and/or BRD4 caught my eye on PubMed just now. The linkages between BET inhibitors and BRD proteins and various metabolic pathways keeps growing and growing!
Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4.
I am particularly interested in the one regarding BRD4 regulation of adiponectin. Adiponectin, at least in mouse models, has been clearly shown to be necessary for adipocyte (fat cells) health. Adiponectin is secreted by the adipocytes and in turn binds to adiponectin receptors on adipocytes to help maintain adipocyte health and also binds to adiponectin receptors on peripheral tissues (such as liver, muscle, etc.). In general, these have effects to promote insulin sensitivity.
Of course, the study cited above are in mouse cells or transgenic mice in which BRD4 is depleted or knocked out, which is different than administering a pan-BET inhibitor or a bromodomain 2 selective BET inhibitor. But it definitely makes me wonder about the beneficial effects of apabetalone on adiponectin and adipose tissue.
BearDownAZ